Article Publish Status: FREE
Abstract Title:

Short and long term variation in ultraviolet radiation and multiple sclerosis.

Abstract Source:

Int J Environ Res Public Health. 2012 Mar ;9(3):685-97. Epub 2012 Feb 24. PMID: 22690156

Abstract Author(s):

Cristina Menni, Walter E Lowell, Joan Bentzen, Roberto Bergamaschi, Filippo Martinelli Boneschi, Vittorio Martinelli, Luisa Bernardinelli, Egon Stenager, George E Davis, Luisa Foco

Article Affiliation:

Department of Applied Health Sciences, University of Pavia, Via Bassi 21, 27100 Pavia, Italy; Email: [email protected] (L.B.); [email protected] (L.F.).


We examined the role of ultraviolet radiation (UVR) in persons diagnosed with multiple sclerosis (MS) in four different populations, Italians, Danish, White and African Americans. We tested whether variation in UVR as determined by seasons (short term variation) and solar cycles (long term variation) is related to MS birth month and to survival as measured by lifespan. Cases were selected from three Italian MS Case Registries (2,737); from the United States National Center for Health Statistics (56,020); and from the Danish Multiple Sclerosis registry (15,900). Chi-square tests were used to study the pattern of month of birth distribution in patients with MS comparing with general population data. T-tests were employed to study solar cycles association with lifespan. A surplus of births was observed in June for White Americans. A decrease of births in October and November, though not significant after multiple testing correction, was observed in the three populations. In White American with MS overall, males and females, we found that solar cycle is associated with lifespan. We found that season and solar cycles have some role in MS susceptibility and life duration. However, this is an exploratory analysis and further work is needed to discern the association.

Study Type : Human Study
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Additional Keywords : Solar Cycle : CK(44) : AC(8)

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