Article Publish Status: FREE
Abstract Title:

Evaluation of small bowel blood flow in healthy subjects receiving low-dose aspirin.

Abstract Source:

World J Gastroenterol. 2011 Jan 14 ;17(2):226-30. PMID: 21245996

Abstract Author(s):

Lynne M Howells, Barbara Gallacher-Horley, Catherine E Houghton, Margaret M Manson, E Ann Hudson

Article Affiliation:

Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo 060-8648, Japan.


AIM: To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow, and the effect of rebamipide.

METHODS: Ten healthy volunteers were enrolled in this study. The subjects were divided into two groups: a placebo group given low-dose aspirin plus placebo and a rebamipide group given low-dose aspirin plus rebamipide for a period of 14 d. Capsule endoscopy and contrast-enhanced ultrasonography were performed before and after administration of drugs. Areas under the curves and peak value of time-intensity curve were calculated.

RESULTS: Absolute differences in areas under the curves were -1102.5 (95% CI: -1980.3 to -224.7, P = 0.0194) in the placebo group and -152.7 (95% CI: -1604.2 to 641.6, P = 0.8172) in the rebamipide group. Peak values of time intensity curves were -148.0 (95% CI: -269.4 to -26.2, P = 0.0225) in the placebo group and 28.3 (95% CI: -269.0 to 325.6, P = 0.8343) in the rebamipide group. Capsule endoscopy showed mucosal breaks only in the placebo group.

CONCLUSION: Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.

Study Type : Human Study

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