Abstract Title:

Short-term memory loss associated with rosuvastatin.

Abstract Source:

Pharmacotherapy. 2006 Aug ;26(8):1190-2. PMID: 16863497

Abstract Author(s):

Laura Galatti, Giovanni Polimeni, Francesco Salvo, Marcello Romani, Aurelio Sessa, Edoardo Spina

Article Affiliation:

Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Messina, Italy. [email protected]


Memory loss and cognitive impairment have been reported in the literature in association with several 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins), but we found no published case reports associated with rosuvastatin. To our knowledge, this is the first reported case of rosuvastatin-related short-term memory loss. A 53-year-old Caucasian man with hypercholesterolemia experienced memory loss after being treated with rosuvastatin 10 mg/day. He had no other concomitant conditions or drug therapies. After discontinuation of rosuvastatin, the neuropsychiatric adverse reaction resolved gradually, suggesting a probable drug association. During the following year, the patient remained free from neuropsychiatric disturbances. Clinicians should be aware of possible adverse cognitive reactions during statin therapy, including rosuvastatin.

Study Type : Human: Case Report

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