Abstract Title:

In vivo toxicity of orally administrated silicon dioxide nanoparticles in healthy adult mice.

Abstract Source:

Environ Sci Pollut Res Int. 2014 Aug 13. Epub 2014 Aug 13. PMID: 25113834

Abstract Author(s):

Ramin Hassankhani, Mohammad Esmaeillou, Ali Asghar Tehrani, Keyvan Nasirzadeh, Fatemeh Khadir, Hamid Maadi

Article Affiliation:

Ramin Hassankhani


The increasing use of silica nanoparticles (SiNPs) in various applications including industrial, agriculture, and medicine has raised concerns about their potential risks to human health. Various nanotoxicity researches have been done on the assessment of SiNPs' toxic effects; however, a few in vivo investigations exist. In this investigation, an in vivo study was done in order to evaluate the oral toxicity of SiNPs. The biochemical levels of 19 different serum parameters were assessed. Moreover, the histopathological changes have been examined as well. We showed that SiNPs with diameters of 10-15 nm in size can cause significant changes in albumin, cholesterol, triglyceride, total protein, urea, HDL, and LDL as well as in alkaline phosphatase and aspartate aminotransferase activity. In addition, histopathological examinations demonstrated that SiNPs have toxic effects on various tissues including liver, kidney, lung, and testis.

Study Type : Animal Study
Additional Links
Anti Therapeutic Actions : Nanotechnology : CK(70) : AC(0)
Problem Substances : Nanoparticles : CK(79) : AC(45)

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