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Article Publish Status: FREE
Abstract Title:

Simultaneous Production of Psilocybin and a Cocktail ofβ-Carboline Monoamine Oxidase Inhibitors in 'Magic' Mushrooms.

Abstract Source:

Chemistry. 2019 Nov 14. Epub 2019 Nov 14. PMID: 31729089

Abstract Author(s):

Felix Blei, Sebastian Dörner, Janis Fricke, Florian Baldeweg, Felix Trottmann, Anna Komor, Florian Meyer, Christian Hertweck, Dirk Hoffmeister

Article Affiliation:

Felix Blei

Abstract:

The psychotropic effects of Psilocybe"magic"mushrooms are caused by the L-tryptophan-derived alkaloid psilocybin. Despite their significance, the secondary metabolome of these fungi is poorly understood in general. Our analysis of four Psilocybe species identified harmane, harmine, and a range of other L-tryptophan-derivedβ-carbolines as their natural products, which was confirmed by 1D and 2D NMR spectroscopy. Stable-isotope labeling with 13C11-L-tryptophan verified the β-carbolines as biosynthetic products of these fungi. In addition, MALDI-MS imaging showed that β-carbolines accumulate toward the hyphal apices.As potent inhibitors of monoamine oxidases, β-carbolines are neuroactive compounds and interfere with psilocybin degradation. Therefore, our findings represent an unprecedented scenario of natural product pathways that diverge from the same building block and produce dissimilar compounds, yet contribute directly or indirectly to the same pharmacological effects.

Study Type : In Vitro Study

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