Simvastatin exhibits neurotoxicity in a neuronal cell model. - GreenMedInfo Summary

Abstract Title:

Simvastatin inhibits the division and induces neurite-like outgrowth in PC12 cells.

Abstract Source:

Neurosci Lett. 1996 Dec 6 ;220(1):21-4. PMID: 8977139

Abstract Author(s):

I Sato-Suzuki, S Murota

Article Affiliation:

Department of Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Japan.

Abstract:

Simvastatin, a potent 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. inhibited cell division in a dose dependent fashion and induced neurite-like outgrowth in PC12 cells. The neurite-like outgrowth was detectable at 0.5 microg/ml of simvastatin 24 h after the treatment. The responses to simvastatin were completely prevented by incubating the cells with mevalonate. In contrast to simvastatin, pravastatin, a similar HMG-CoA reductase inhibitor but lipophobic, had no effect on the cells. The results provide new possibilities for the central nervous system (CNS) side effects of simvastatin therapy.

Article Published Date : Dec 06, 1996

Study Type : In Vitro Study

Additional Links

Diseases : Brain Damage : CK(129) : AC(63), Neurotoxicity : CK(48) : AC(26), Statin-Induced Pathologies : CK(1848) : AC(369)

Pharmacological Actions : Antiproliferative : CK(6801) : AC(6958), Enzyme Inhibitors : CK(692) : AC(392)

Problem Substances : Simvastatin : CK(791) : AC(165)

Adverse Pharmacological Actions : Neurotoxic : CK(2715) : AC(657)