Simvastatin has been reported to cause cholestatic hepatitis. - GreenMedInfo Summary
Acute cholestatic hepatitis during simvastatin administration.
Recenti Prog Med. 1991 Apr ;82(4):233-5. PMID: 1857844
Divisione di Medicina generale II, Ospedale Maggiore, Novara.
Simvastatin, recently introduced in clinical practice for pharmacological treatment of hypercholesterolemia, has been found to cause minor and reversible elevations of serum transaminases. We report a case of acute cholestatic hepatitis during simvastatin therapy. Clinical, biochemical, immunological, and histological findings were consistent with a simvastatin-induced liver damage through an immunological-mediated mechanism. This case suggests a careful monitoring of liver function tests during simvastatin therapy, and caution in continuing simvastatin administration when elevations of serum transaminases take place.