-Sitosterol derived compound from onion husks non-polar fraction reduces quorum sensing controlled virulence and biofilm production.
Saudi Pharm J. 2019 Jul ;27(5):664-672. Epub 2019 Apr 4. PMID: 31297021
Hanan M Al-Yousef
Quorum sensing is an important regulatory factor ofvirulence induction such as BF, motility, formations of proteases, pyocyanin, and some toxins. The aim of the current study is to detect the effect of the pet.ether extract from onion husk and compound drive from it on quorum sensing and virulence formations of. Quorum sensing inhibiting effect of the pet.ether extract of onion husk and a compound drive from it, was evaluated byreporter using dilution method as well as an antioxidant by using DPPH. The efficacious of: Quorum sensing inhibiting on pet.ether fraction and compound derived from it, were investigated for their activities toward biofilm and pyocyanin synthesis as well as motility from. The pet.ether fraction and compound derived from it of onion husk exhibited potent antimicrobial, antioxidant and Quorum sensing inhibiting effects. The pet.ether fraction and compound derived from it possesses significant reduction on pyocyanin and biofilm induction of. Moreover, they significantly inhibited swimming motilities of. For the first time, our study showed the medical importance ofL. as antimicrobial, antioxidant as well as Quorum sensing inhibiting and virulence suppressors of. Thus, these might emphasized onL as a natural source for attenuating toxins of the.