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Abstract Title:

Effect of Vitamin D Supplementation on Inflammatory Markers in Non-Obese Lebanese Patients with Type 2 Diabetes: A Randomized Controlled Trial.

Abstract Source:

Nutrients. 2020 Jul 9 ;12(7). Epub 2020 Jul 9. PMID: 32659891

Abstract Author(s):

Cynthia El Hajj, Stéphane Walrand, Mariana Helou, Kaissar Yammine

Article Affiliation:

Cynthia El Hajj


BACKGROUND: A low serum 25-hydroxyvitamin D (25(OH) D) concentration has been associated with a higher risk of type 2 diabetes mellitus (T2DM), especially in older people. Our aim in this randomized controlled trial was to evaluate the effect of vitamin D treatment on inflammatory markers in non-obese Lebanese patients with T2DM, living in Beirut, Lebanon.

METHODS: Non-Obese patients with T2DM (= 88), deficient/insufficient in vitamin D, were randomly assigned into one of two groups-a treatment group receiving 30,000 IU cholecalciferol/week for a period of six months, and a placebo group. Serum concentrations of TNF-α, high-sensitivity C-reactive protein (hs-CRP), and Interleukin-6 (IL-6) were the primary outcomes. A homeostatic model of insulin resistance (HOMA-IR) was assessed, in addition to serum concentrations of fasting blood glucose (FBG), HbA1C, (25(OH) D), and PTH.

RESULTS: The vitamin D group showed higher blood levels of (25(OH) D) (<0.0001), and a significant reduction in hs-CRP and TNF-α concentrations (<0.0001) compared to placebo. The decrease perceived in IL-6 concentrations was not significant (= 0.1). No significant changes were seen in FBG (= 0.9) and HbA1c levels (= 0.85).

CONCLUSION: Six months of vitamin D supplementation led to a decrease in some inflammatory markers in patients with T2DM. Additional studies with a larger sample and a longer period are advised in this regard. This trial was registered at ClinicalTrial.gov; Identifier number: NCT03782805.

Study Type : Human Study

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