Abstract Title:

Chromosome damage induced by selenium salts in human peripheral lymphocytes.

Abstract Source:

Toxicol In Vitro. 2000 Oct;14(5):405-8. PMID: 10963956

Abstract Author(s):

S Biswas, G Talukder, A Sharma

Article Affiliation:

Department of Pathology, Vivekananda Institute of Medical Sciences, Calcutta, India. [email protected]


Two inorganic salts of selenium, sodium selenite (Na(2)SeO(3)) and sodium selenate (Na(2)SeO(4)), were screened for damage to chromosome and cell division following exposure to human lymphocyte cultures. In vitro exposure of human peripheral blood lymphocytes to high concentration of two inorganic salts of selenium-sodium selenite (2.9 x 10(-5) M) and sodium selenate (2.65 x 10(-5) M)-was found to be lethal; no blast cells being formed. Lower concentrations of both salts, 5.8 x 10(-6) M and 1.06 x 10(-5) M, respectively, were highly mitostatic. Lower concentrations of sodium selenite (2.9 x 10(-6) M, 1.16 x 10(-6) M and 2.32 x 10(-7) M) and sodium selenate (5.3 x 10(-6) M, 2.65 x 10(-6) M and 1.06 x 10(-6) M), respectively, induced chromosomal aberrations and reduced cell division in proportions directly related to the dose. Sodium selenite was considerably more clastogenic than sodium selenate.

Study Type : In Vitro Study

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