Abstract Title:

The inactivation of herpes simplex virus by some Solanaceae glycoalkaloids.

Abstract Source:

Antiviral Res. 1985 Dec ;5(6):335-43. PMID: 3004327

Abstract Author(s):

H V Thorne, G F Clarke, R Skuce


The infectivity of herpes simplex virus Type I in tissue culture was inhibited by prior incubation with aqueous suspensions of glycoalkaloids in order of activity alpha-chaconine greater than alpha-tomatine greater than alpha-solasonine but not by the corresponding aglycones, solanidine, tomatidine and solasodine. However, inhibition was not only dependent on the presence of a sugar moiety since the glycone alpha-solanine was inactive under the conditions used. The glycones, but not the aglycones, showed cytopathic effects on cellular membranes of Vero cells and erythrocytes; therefore, it is suggested that inactivation of virus results from insertion of the glycones into the viral envelope.

Study Type : In Vitro Study

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