Abstract Title:

Soy protein influences the development of the metabolic syndrome in male obese ZDFxSHHF rats.

Abstract Source:

Horm Metab Res. 2005 May;37(5):316-25. PMID: 15971156

Abstract Author(s):

J Davis, M J Iqbal, J Steinle, J Oitker, D A Higginbotham, R G Peterson, W J Banz


Previous investigations have demonstrated a marked effect of soy protein on the metabolic syndrome (MS). The purpose of this preliminary study was to identify the effects of soy-based diets on male obese ZDFxSHHF (fa/ fa-cp/?) rats. Animals were randomly assigned to one of four diets: control, casein (C); low-isoflavone (LIS) soy protein; high-isoflavone (HIS) soy protein; or casein + rosiglitazone (CR). Physiological, biochemical, and molecular parameters were determined at sacrifice. Body weight (p<0.01) and food intake (p<0.05) were lower in LIS-fed rodents. Rosiglitazone-treated animals had higher body weight and adiposity (p<0.05). LIS and CR groups exhibited better glycemic control (p<0.05), but with a limited effect in rosiglitazone-treated animals. HIS fed rats had higher glucose and triacylglyceride levels (p<0.01), and lower plasma insulin (p<0.01). Renal function parameters with the exception of an increase in systolic blood pressure (p<0.05) were all suppressed in the LIS group (p<0.01). The CR group had twofold PPARalpha and PPARgamma mRNA abundance (p<0.01). LIS-fed animals also exhibited greater abundance of PPARgamma mRNA (p<0.001), and nearly threefold FAS and CPT-1 mRNA levels (p<0.05). HIS-fed rats also had higher abundance of CPT-1 mRNA, as well as a lower abundance of ACC mRNA (p<0.05). Soy-based diets, influenced by isoflavone content and distinct from rosiglitazone, improved several metabolic parameters in obese ZDFxSHHF rats.

Study Type : Animal Study

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