Article Publish Status: FREE
Abstract Title:

Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures.

Abstract Source:

Environ Health Perspect. 2016 Jun 10. Epub 2016 Jun 10. PMID: 27285288

Abstract Author(s):

Christine G Parks, Jane A Hoppin, Anneclaire J DeRoos, Karen H Costenbader, Michael C Alavanja, Dale P Sandler

Article Affiliation:

Christine G Parks


BACKGROUND: Farming has been associated with rheumatoid arthritis (RA), but the role of pesticides is not known.

OBJECTIVES: We examined associations between RA and pesticides or other agricultural exposures among female spouses of licensed pesticide applicators in the Agricultural Health Study.

METHODS: Women were enrolled 1993-1997 and followed through 2010. Cases (N=275 total, 132 incident), confirmed by a physician or by self-reported use of disease modifying anti-rheumatic drugs), were compared with non-cases (N=24,018). Odds ratios (OR) and 95% Confidence Intervals (CI) were estimated using logistic regression models adjusted for age, state and smoking pack-years.

RESULTS: Overall, women with RA were somewhat more likely to have reported lifetime use of any specific pesticide versus no pesticides (OR=1.4; 95%CI 1.0, 1.6). Of 15 pesticides examined, maneb/mancozeb (OR=3.3; 95%CI 1.5, 7.1) and glyphosate (OR=1.4; 95%CI 1.0, 2.1) were associated with incident RA compared with no pesticide use. An elevated, but non-statistically significant association with incident RA was seen for DDT (OR=1.9; 95%CI 0.97, 3.6). Incident RA was also associated with the application of chemical fertilizers (OR=1.7; 95%CI 1.1, 2.7) and cleaning with solvents (OR=1.6; 95%CI 1.1, 2.4), but inversely associated with lifetime livestock exposure as a child and adult (OR=0.48; 95%CI 0.24, 0.97) compared with no livestock exposure.

CONCLUSIONS: Our results suggest that specific agricultural pesticides, solvents and chemical fertilizers may increase risk of RA in women, while exposures involving animal contact may be protective.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022, Journal Articles copyright of original owners, MeSH copyright NLM.