(Rosemary) Extracts Containing Carnosic Acid and Carnosol are Potent Quorum Sensing Inhibitors ofVirulence.
Antibiotics (Basel). 2020 Mar 31 ;9(4). Epub 2020 Mar 31. PMID: 32244277
is an opportunistic pathogen and a common cause of skin infection.also plays a role in the pathogenesis of the chronic inflammatory skin disease, atopic dermatitis.virulence involves activation of the quorum sensingoperon. In this paper, we show that the diterpene carnosic acid, present in. (rosemary) leaves, is a specific inhibitor ofexpression as low as 5μM. Carnosol and rosmarinic acid are two other phytochemicals present in rosemary leaves. Carnosol, but not rosmarinic acid, is also a potentexpression inhibitor. Natural rosemary extracts containing carnosic acid and carnosol inhibitexpression, both in luciferase reporter strains and in wild type strains isolated from patients with atopic dermatitis. Specific inhibition ofvirulence using topical formulations of rosemary extract may offer a practical approach to preventing and treating flares of atopic dermatitis.