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Article Publish Status: FREE
Abstract Title:

Spectral Analysis and Antiulcer Potential ofthrough the Amelioration of Proinflammatory Cytokines and Apoptosis Markers.

Abstract Source:

Life (Basel). 2022 Oct 19 ;12(10). Epub 2022 Oct 19. PMID: 36295076

Abstract Author(s):

Rahamat Unissa Syed, Sivakumar S Moni, Amr S Abu Lila, Marwa H Abdallah, Amr S Abouzied, Humera Banu, Khetam Saad Mutni Alreshidi, Badriah Mansour Wadid Alrashidi, Mohd Abdul Hadi, Hemat El-Horany, Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha

Article Affiliation:

Rahamat Unissa Syed

Abstract:

The objective of this study was to characterize the bioactive ingredients and antiulcer effects of. Several bioactive chemicals were found in the cold methanolic extract ofleaves after gas chromatography-mass spectrometry (GC-MS) research: 9,12-octadecadienoic acid (Z,Z)-, cyclononasiloxane, octadecamethyl-, n-hexadecanoic acid, Hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl, octadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, 9-octadecenamide, (Z)-, hexadecanoic acid, stigmasterol, benzothiazole, ethyl iso-allocholate, and octacosane. Distinct fingerprint regions in GCMS indicated the existence of bioactive compounds. The leaf powder of(LPL) demonstrated substantial antiulcer properties at 400 mg/kg, which was almost equivalent to the standard drug at 20 mg/kg. The cytokine network was efficiently regulated by reducing the production of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α. The levels of caspase-3 and caspase-9 were also considerably lowered at< 0.05 significant level.

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