Abstract Title:

Effect of spinach aqueous extract on wound healing in experimental model diabetic rats with streptozotocin.

Abstract Source:

J Sci Food Agric. 2016 May ;96(7):2337-43. Epub 2015 Sep 8. PMID: 26201288

Abstract Author(s):

Sara Rahati, Mohammadreza Eshraghian, Abdolali Ebrahimi, Hamideh Pishva

Article Affiliation:

Sara Rahati


BACKGROUND: Chronic ulcer is still a serious issue for diabetic patients. Diabetes is a prevalent cause of ulcer regeneration delay and (or) disruption. Since Spinacia oleracea extract contains compounds with anti-oxidative and anti-inflammatory effects, this may be effective in accelerating the healing process of ulcers, especially diabetic ulcers. Hence, this study examined the effect of Spinacia oleracea aqueous extract on ulcer regeneration in an experimental animal model.

RESULTS: Macroscopic examination of the wounds of the control group and spinach aqueous extract group between 7 and 21 days compared with diabetic group, significant changes were observed (P<0.05). On microscopic examination, epithelial tissue formation, formation of granulation tissue and new blood vessels in the spinach aqueous extract group and non-diabetic group compared to the diabetic group showed significant improvements (P<0.05). Also, significant differences in vascular endothelial growth factor were observed between groups on days 3 and 7 (P<0.05).

CONCLUSION: The Spinacia oleracea aqueous extract can be effective in regenerating diabetic ulcers. It affects the speed and structure of the ulcer.© 2015 Society of Chemical Industry.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.