Abstract Title:

Evaluation of the Mitigation Effect of Spirulina Against Lung Injury Induced by Radiation in Rats.

Abstract Source:

Curr Radiopharm. 2022 Apr 18. Epub 2022 Apr 18. PMID: 35440331

Abstract Author(s):

Mohammad Hootan Ahmadvand, Safoora Nikzad, Vahid Changizi, Abdolazim Sedighi Pashaki, Masoud Najafi, Fatemeh Mirzaei

Article Affiliation:

Mohammad Hootan Ahmadvand


BACKGROUND: Some compounds have been investigated to mitigate the effect of radiation on the lung, such as pneumonitis and fibrosis.

OBJECTIVE: This study aimed to examine the mitigation efficiency of Spirulina compared to the effect of Metformin.

METHODS: 25 male Wistar rats were allotted into five groups: control, Spirulina, Radiation, Radiation plus Spirulina, Radiation plus Metformin. Rat chest regions were irradiated by 15 Gray (Gy) x-radiation using a LINAC. Forty-eight hours after irradiation, treatment with Spirulina and Metformin began. Eighty days after irradiation, all rats were sacrificed, and their lung tissues were removed for histopathological, and biochemical assays.

RESULTS: The results demonstrated that irradiation increased MDA (Malondialdehyde) levels while suppressing the SOD (superoxide dismutase) and GPx (glutathione peroxidase) activity in the irradiated group. MDA levels in lung tissues were reduced with Metformin but not with Spirulina. Metformin and Spirulina both increased the SOD and GPx activity in lung tissue. Moreover, histopathological evaluations showed extensive changes in lung tissue include infiltration of lymph cells around the bronchioles and blood vessels, thickening of the alveolar wall, and the disruption of the alveolar structure, as well as accumulation of collagen fibers. Administration of Spirulina and Metformin significantly reduced pathological changes in lung tissue, although the effect of Metformin was greater than that of Spirulina.

CONCLUSION: Spirulina could mitigate radiation-induced lung injury moderately, although Metformin is more effective than Spirulina as a mitigator agent.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.