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Article Publish Status: FREE
Abstract Title:

Spontaneous Regression of Advanced Hepatocellular Carcinoma.

Abstract Source:

Case Rep Gastroenterol. 2020 Sep-Dec;14(3):491-496. Epub 2020 Oct 15. PMID: 33250687

Abstract Author(s):

Dhiraj J Sonbare, Rupal Bandi, Vivek Sharma, Thomas Cacciarelli, Obaid S Shaikh

Article Affiliation:

Dhiraj J Sonbare

Abstract:

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. The tumor carries poor prognosis with curative therapeutic options limited to surgical resection, tumor ablation, and liver transplantation. Rarely, there is spontaneous regression of the tumor. We describe the case of a 74-year-old male with cirrhosis from non-alcoholic steatohepatitis who developed advanced HCC that was associated with tumor invasion of the portal vein and marked elevation of serum alfa-fetoprotein level. The patient received no cancer-specific therapy. However, 1 year after the initial diagnosis, he was noted to have complete regression of the tumor. In this report, we discuss possible mechanisms of spontaneous tumor regression and its therapeutic implications.

Study Type : Human: Case Report

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