Abstract Title:

Spontaneous Regression of a Middle Ear Melanoma.

Abstract Source:

Otol Neurotol. 2021 Sep 30. Epub 2021 Sep 30. PMID: 34607999

Abstract Author(s):

Iris Krebbers, Henricus P M Kunst, Laura W J Baijens, Mari F C M van den Hout, Jerome J Waterval

Article Affiliation:

Iris Krebbers


OBJECTIVE: To describe a case of complete spontaneous regression of a middle ear melanoma.

PATIENT: We present a case of a 68-year-old man with complaints of unilateral hearing loss and an ipsilateral facial nerve paresis. Radiological and histopathological examination revealed a cT4bN0M0 mucosal melanoma of the middle ear.

INTERVENTIONS: The patient underwent a subtotal petrosectomy and postoperative radiotherapy.

MAIN OUTCOME MEASURE: Computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography/computed tomography with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG-PET-CT), and histopathological examination.

RESULTS: After subtotal petrosectomy, histopathological examination of the resection specimen showed only fibrosis and a histiocytic and clonal T-cell infiltration, but no residual melanoma at the primary tumor site, consistent with spontaneous tumor regression. Follow-up MRI scanning 6 and 12 months after radiotherapy showed no signs of tumor recurrence.

CONCLUSIONS: This case describes the concept of spontaneous regression of a mucosal melanoma of the middle ear. Spontaneous tumor regression at this location has not been described before.

Study Type : Human: Case Report
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