Abstract Title:

Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo.

Abstract Source:

J Neurosci. 2008 Dec 10 ;28(50):13609-14. PMID: 19074034

Abstract Author(s):

Steve Klopfleisch, Doron Merkler, Matthias Schmitz, Sabine Klöppner, Mariann Schedensack, Gunnar Jeserich, Hans H Althaus, Wolfgang Brück

Article Affiliation:

Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.


Statins are widely prescribed drugs in cardiovascular diseases. Recent studies also demonstrated anti-inflammatory and immunomodulatory properties of statins by modulating the activity of small GTPases. Statins are thus considered as potential therapeutic drug for the inflammatory demyelinating disease multiple sclerosis (MS). However, little is known about the effects of statins on myelin-forming oligodendrocytes. Here, we show that statins hamper process and myelin formation in vitro by interfering with Ras and Rho signaling in mature oligodendrocytes and provide evidence that statins impair ongoing remyelination in vivo. Our findings may have significant implications for the application of statins in MS patients and in other demyelinating diseases of the CNS.

Study Type : Animal Study

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