Statin-induced vasculitis has been reported. - GreenMedInfo Summary

Abstract Title:

ANCA-positive vasculitis associated with simvastatin/ezetimibe: expanding the spectrum of statin-induced autoimmunity?

Abstract Source:

Int J Rheum Dis. 2010 Aug ;13(3):e29-31. PMID: 20704607

Abstract Author(s):

Deepali Sen, Elliot D Rosenstein, Neil Kramer

Article Affiliation:

Department of Medicine, Saint Barnabas Medical Center, Livingston, NJ 07039, USA.

Abstract:

Although autoimmune syndromes such as systemic lupus erythematosus and dermatomyositis have been previously reported in association with statin use, vasculitis has not been well described. We present a patient with an antineutrophil cytoplasmic antibody-positive, predominantly cutaneous vasculitis, the temporal course of which was associated with simvastatin/ezetimibe use. The patient's serologic findings were consistent with drug-induced disease, with high titer antimyeloperoxidase, in addition to antinuclear and anti-Ro (SSA) antibodies. The patient demonstrated complete resolution of symptoms simply by withdrawing the drug.

Article Published Date : Aug 01, 2010

Study Type : Human: Case Report

Additional Links

Diseases : Autoimmune Diseases : CK(11871) : AC(2599), Statin-Induced Pathologies : CK(1852) : AC(370), Vasculitis : CK(76) : AC(17)

Pharmacological Actions : Anticholesteremic Agents : CK(4038) : AC(663)

Problem Substances : Simvastatin : CK(793) : AC(165), Statin Drugs : CK(4608) : AC(560)

Adverse Pharmacological Actions : Immunosuppressive : CK(289) : AC(55)