Abstract Title:

Statins provoking MELAS syndrome. A case report.

Abstract Source:

Eur Neurol. 2007 ;57(4):232-5. Epub 2007 Mar 26. PMID: 17389800

Abstract Author(s):

Joseph E Thomas, Nora Lee, Paul D Thompson

Article Affiliation:

Department of Internal Medicine, School of Medicine, University of Connecticut, Farmington, Conn., USA. [email protected]


BACKGROUND: Statins inhibit the production of 2,3-dimethoxy,5-methyl,6-polyisoprene parabenzoquinone also known as ubiquinone or coenzyme Q10 (CoQ10), which is required for mitochondrial electron transport. Idiopathic or primary CoQ10 deficiencies have been known to cause mitochondrial encephalomyopathy.

METHODS: We present the case of a patient with mitochondrial syndrome, consisting of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), whose symptoms were temporally related to statin therapy.

CONCLUSION: Statins may provoke symptoms related to MELAS in susceptible individuals.

Study Type : Human: Case Report

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