Abstract Title:

Structural characterisation and immunomodulatory activity of polysaccharides from white asparagus skin.

Abstract Source:

Carbohydr Polym. 2020 Jan 1 ;227:115314. Epub 2019 Sep 14. PMID: 31590844

Abstract Author(s):

Nifei Wang, Xiaojun Zhang, Shaowei Wang, Qingbin Guo, Zhenjing Li, Huanhuan Liu, Changlu Wang

Article Affiliation:

Nifei Wang


The physicochemical properties, structural features and immunomodulatory effects of the white asparagus (Asparagus officinalis L.) skin polysaccharides (WASP) were systematically studied. WASP showed a pectic-like structure with a relatively low degree of esterification (DE, 18%); the weight-average molecular weight (Mw) and intrinsic viscosity were 76.1 kDa and 13 mL/g, respectively. Structurally, the dominated sugar residue of WASP was 4-α-D-GalpA (39.7 mol%), while other residues including α-L-Araf, 3-α-L-Rhap, 2,4-α-L-Rhap, and 4-β-D-Galp were also detected with a comparable amount. A proposed structure of WASP was also presented. Physiologically, WASP could modulate the immune response of RAW 264.7 macrophages through increasing the release of immune factors (IL-6, TNF-α and IL-10) and improving the expression of mRNA. To conclude, the pectic-like polysaccharides from white asparagus (Asparagus officinalis L.) skin could be potentially used as an immunomodulatory agent in functional food.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(4048) : AC(1475)

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