n/a
Article Publish Status: FREE
Abstract Title:

Structural Characterization and Anti-breast Cancer Activityof a Novel Polysaccharide From.

Abstract Source:

Front Nutr. 2022 ;9:911838. Epub 2022 May 11. PMID: 35634368

Abstract Author(s):

Yi Chen, Saifeng Qiao, Huiping Liu, Huizhen Xing, Pei Chen

Article Affiliation:

Yi Chen

Abstract:

is an important functional food, widely used for flavoring in Africa and South America. In this study, a novel high-molecular-weight polysaccharide (CCP) fromwas extracted, and its structural characteristics and anti-breast cancer activitywere investigated. CCP contained bothα and β configurations and mainly composed of galactose (36.89%), arabinose (23.97%), glucose (18.35%) and rhamnose (9.36%) with an average molecular weight of 1.98 × 10Da. The main glycosyl residues of CCP detected by methylation analysis were 1,3,6-linked Gal, 1,3-linked Glc, 1,5-linked Ara, T-Ara, and T-Rha.experiments suggested that CCP significantly inhibited the proliferation of MDA-MB-231 cells, decreased the expressions of cyclin D1 and CDK4 and stocked cells at G/Gphase. Meanwhile, the typical morphological features of apoptotic cells were also observed. Combining with the consequences of Annexin V-FITC/PI staining, Hoechst 33258 staining and western blot analysis, CCP induced apoptosis of MDA-MB-231 cells by triggering the Fas/FasL-mediated death receptor pathway. Overall, these results provide a theoretical basis for the application ofpolysaccharide as a potential anti-breast cancer agent in functional food and medicine.

Study Type : In Vitro Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.