Article Publish Status: FREE
Abstract Title:

Structural Characterization and Anti-breast Cancer Activityof a Novel Polysaccharide From.

Abstract Source:

Front Nutr. 2022 ;9:911838. Epub 2022 May 11. PMID: 35634368

Abstract Author(s):

Yi Chen, Saifeng Qiao, Huiping Liu, Huizhen Xing, Pei Chen

Article Affiliation:

Yi Chen


is an important functional food, widely used for flavoring in Africa and South America. In this study, a novel high-molecular-weight polysaccharide (CCP) fromwas extracted, and its structural characteristics and anti-breast cancer activitywere investigated. CCP contained bothα and β configurations and mainly composed of galactose (36.89%), arabinose (23.97%), glucose (18.35%) and rhamnose (9.36%) with an average molecular weight of 1.98 × 10Da. The main glycosyl residues of CCP detected by methylation analysis were 1,3,6-linked Gal, 1,3-linked Glc, 1,5-linked Ara, T-Ara, and T-Rha.experiments suggested that CCP significantly inhibited the proliferation of MDA-MB-231 cells, decreased the expressions of cyclin D1 and CDK4 and stocked cells at G/Gphase. Meanwhile, the typical morphological features of apoptotic cells were also observed. Combining with the consequences of Annexin V-FITC/PI staining, Hoechst 33258 staining and western blot analysis, CCP induced apoptosis of MDA-MB-231 cells by triggering the Fas/FasL-mediated death receptor pathway. Overall, these results provide a theoretical basis for the application ofpolysaccharide as a potential anti-breast cancer agent in functional food and medicine.

Study Type : In Vitro Study

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