Abstract Title:

Structure and cytotoxic activity of ulvan extracted from green seaweed Ulva lactuca.

Abstract Source:

Int J Biol Macromol. 2016 Dec ;93(Pt A):695-702. Epub 2016 Sep 13. PMID: 27637450

Abstract Author(s):

Thi Thu Thuy Thanh, Thi Minh Thu Quach, Thi Nu Nguyen, Dang Vu Luong, Minh Ly Bui, Thi Thanh Van Tran

Article Affiliation:

Thi Thu Thuy Thanh


The structure of an ulvan obtained by water extraction from green seaweed Ulva lactuca was elucidated by using IR, NMR, SEC-MALL and ESIMS methods. The ulvan was also evaluated for its cytotoxic effects on three human cancer cell lines. The results showed that the ulvan was composed of rhamnose, galactose, xylose, manose, glucose (with a mole ratio of Rha: Gal: Xyl: Man: Glu equal to 1: 0.03: 0.07: 0.01: 0.06), uronic acid (21.5%) and sulfate content (18.9%) with a molecular weight of 347000. This ulvan mainly consists of disaccharide [→4)-β-d-GlcA-(1→4)-α-l-Rha3S-(1→] and other minor disaccharide β-GlcA-(1→2)-α-Xyl and β-GlcA-(→2)-α-Rha. The ulvan showed a significant cytotoxic activity against hepatocellular carcinoma (IC29.67±2.87μg/ml), human breast cancer (IC25.09±1.36μg/ml), and cervical cancer (IC36.33±3.84μg/ml).

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.