Abstract Title:

Colorectal cancer: an update on the effects of lycopene on tumor progression and cell proliferation.

Abstract Source:

J Biol Regul Homeost Agents. 2017 09 30 ;31(3). Epub 2017 Sep 30. PMID: 28685524

Abstract Author(s):

F Carini, S David, G Tomasello, M Mazzola, P Damiani, F Rappa, L Battaglia, A Gerges Geagea, R Jurjus, A Leone

Article Affiliation:

F Carini


Colorectal cancer (CRC) is one of the most common cancers worldwide. Various factors, including oxidative stress, where excessive productions of reactive oxygen species (ROS) and reactive nitrogen species (RNS) occur, contribute to its pathogenesis. Numerous studies have investigated the effect of antioxidant substances derived from food such as fruits and vegetables; however, data on Lycopene are still rare. Studies on HT-29 colorectal cancer cells and on animal models have shown that lycopene has effects on cell proliferation and on the progression of the CRC by interacting with various cellular signaling pathways. This analysis of the literature focused on the antioxidant effect of lycopene, a substance that is found in the tomato.

Study Type : Review

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