Abstract Title:

Anti-inflammatory and anti-oxidant activity of polyphenolic extracts from Lactuca sativa (var. Maravilla de Verano) under different farming methods.

Abstract Source:

J Sci Food Agric. 2016 Jan 18. Epub 2016 Jan 18. PMID: 26777118

Abstract Author(s):

Simona Adesso, Giacomo Pepe, Eduardo Sommella, Michele Manfra, Antonio Scopa, Adriano Sofo, Gian Carlo Tenore, Mariateresa Russo, Francesca Di Gaudio, Giuseppina Autore, Pietro Campiglia, Stefania Marzocco

Article Affiliation:

Simona Adesso


BACKGROUND: Besides their nutritional value, vegetables are a source of healthy-promoting compounds, such as polyphenols, and their content can be influenced by the particular farming method. In this study polyphenolic extracts from Lactuca sativa (var. Maravilla de verano) plants cultivated with different farming methods were chemically characterized and tested in vitro and ex vivo inflammation models.

RESULTS: The tested extacts (250-2.5µg/mL) were able to reduce both the inflammatory and oxidative stress in LPS-stimulated J774A.1 murine monocyte macrophage cells, by lowering the release of nitric oxide (NO) and reactive oxygen species (ROS) and promoting nuclear traslocation of Nuclear factor (erythroid-derived 2)-like 2; (Nrf2)and nuclear factor-κB (NF-κB). In this regard, quantitative profiles revealed different amounts of polyphenols, in particular quercetin levels were higher in plants under mineral fertilized treatment. Those extract showed an enhanced anti-inflammatory and antioxidant activity.

CONCLUSION: Our data showed the anti-inflammatory and antioxidant potential of Maravilla de Verano polyphenolic extracts. The effect of farming methods on polyphenolic levels was highlighted. The higher reduction of inflammatory mediators release in extracts from plants cultivated under mineral fertilization treatment was correlated to the higher amount of quercetin. These results can be useful for both nutraceutical or agronomic purposes.

Study Type : In Vitro Study

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