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Article Publish Status: FREE
Abstract Title:

The Potential of Carnosine in Brain-Related Disorders: A Comprehensive Review of Current Evidence.

Abstract Source:

Nutrients. 2019 May 28 ;11(6). Epub 2019 May 28. PMID: 31141890

Abstract Author(s):

Martin Schön, Aya Mousa, Michael Berk, Wern L Chia, Jozef Ukropec, Arshad Majid, Barbara Ukropcová, Barbora de Courten

Article Affiliation:

Martin Schön

Abstract:

Neurological, neurodegenerative, and psychiatric disorders represent a serious burden because of their increasing prevalence, risk of disability, and the lack of effective causal/disease-modifying treatments. There is a growing body of evidence indicating potentially favourable effects of carnosine, which is an over-the-counter food supplement, in peripheral tissues. Although most studies to date have focused on the role of carnosine in metabolic and cardiovascular disorders, the physiological presence of this di-peptide and its analogues in the brain together with their ability to cross the blood-brain barrier as well as evidence from in vitro, animal, and human studies suggest carnosine as a promising therapeutic target in brain disorders. In this review, we aim to provide a comprehensive overview of the role of carnosine in neurological, neurodevelopmental, neurodegenerative, and psychiatric disorders, summarizing current evidence from cell, animal, and human cross-sectional, longitudinal studies, and randomized controlled trials.

Study Type : Review

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