Article Publish Status: FREE
Abstract Title:

Anti-allodynia effect of safranal on neuropathic pain induced by spinal nerve transection in rat.

Abstract Source:

Int J Clin Exp Med. 2014 ;7(12):4990-6. Epub 2014 Dec 15. PMID: 25663997

Abstract Author(s):

Ke-Jun Zhu, Ji-Shun Yang

Article Affiliation:

Ke-Jun Zhu


In this study, we investigated the anti-allodynia effect of safranal, the main volatile constitute of saffron, in spinal nerve transection model of rats. Meanwhile, to elucidate the mechanism, we determined the dynamic expression changes of glial activation markers (GFAP and OX-42) and inflammatory cytokines (TNF-α and IL-1β) in ipsilateral dorsal horn of lumbar enlargement post surgery. Results showed significant increase of these markers along with development of mechanical allodynia. Safranal (0.1 mg/kg, i.p.) attenuated the pain sensitivity and inhibited the expression of these markers. The results demonstrate that the antiallodynia effect of safranal after nerve injury might be attributed to its inhibiting effect on glial activation and inflammatory cytokine production in central nervous system.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022, Journal Articles copyright of original owners, MeSH copyright NLM.