Abstract Title:

Chronic arthritis after rubella vaccination.

Abstract Source:

Clin Infect Dis. 1992 Aug ;15(2):307-12. PMID: 1520764

Abstract Author(s):

C P Howson, M Katz, R B Johnston, H V Fineberg

Article Affiliation:

C P Howson


In August 1991 the Institute of Medicine released a report entitled"Adverse Effects of Pertussis and Rubella Vaccines"that examined, among other relations, the relation between immunization with the RA 27/3 rubella vaccine strain and chronic arthritis. The committee spent 20 months reviewing a wide range of information sources including case series and individual case reports published in peer-reviewed journals and reported by vaccine manufacturers; unpublished case reports from physicians, parents, and other concerned persons; epidemiological studies; and laboratory studies. There were no animal studies available. The committee found that the evidence is consistent with a causal relation between the RA 27/3 rubella vaccine strain and chronic arthritis in adult women, although the evidence is limited in scope. Proving that rubella vaccination can cause chronic arthritis will require a better understanding of pathogenetic mechanisms and additional well-designed studies. We briefly describe the committee's evaluative methods and present the evidence underlying its conclusion.

Study Type : Human Study
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