Article Publish Status: FREE
Abstract Title:

Low neural exosomal levels of cellular survival factors in Alzheimer's disease.

Abstract Source:

Ann Clin Transl Neurol. 2015 Jul ;2(7):769-73. Epub 2015 May 13. PMID: 26273689

Abstract Author(s):

Edward J Goetzl, Adam Boxer, Janice B Schwartz, Erin L Abner, Ronald C Petersen, Bruce L Miller, Olga D Carlson, Maja Mustapic, Dimitrios Kapogiannis

Article Affiliation:

Edward J Goetzl


Transcription factors that mediate neuronal defenses against diverse stresses were quantified in plasma neural-derived exosomes of Alzheimer's disease or frontotemporal dementia patients and matched controls. Exosomal levels of low-density lipoprotein receptor-related protein 6, heat-shock factor-1, and repressor element 1-silencing transcription factor all were significantly lower in Alzheimer's disease patients than controls (P < 0.0001). In frontotemporal dementia, the only significant difference was higher levels of repressor element 1-silencing transcription factor than in controls. Exosomal transcription factors were diminished 2-10 years before clinical diagnosis of Alzheimer's disease. Low exosomal levels of survival proteins may explain decreased neuronal resistance to Alzheimer's disease neurotoxic proteins.

Study Type : Human Study
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Additional Keywords : Exosomes : CK(312) : AC(199)

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