This study found that inflammatory response was a very important mechanism in two diseases of opposite phenotypes, that is, cancer (cell survival) and Alzheimer's disease (cell death). - GreenMedInfo Summary
Network Comparison of Inflammation in Colorectal Cancer and Alzheimer's Disease.
Biomed Res Int. 2015 ;2015:205247. Epub 2015 Jul 26. PMID: 26273596
Sungjin Park
Recently, a large clinical study revealed an inverse correlation of individual risk of cancer versus Alzheimer's disease (AD). However, no explanation exists for this anticorrelation at the molecular level; however, inflammation is crucial to the pathogenesis of both diseases, necessitating a need to understand differing signaling usage during inflammatory responses distinct to both diseases. Using a subpathway analysis approach, we identified numerous well-known and previously unknown pathways enriched in datasets from both diseases. Here, we present the quantitative importance of the inflammatory response in the two disease pathologies and summarize signal transduction pathways common to both diseases that are affected by inflammation.