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Abstract Title:

Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Linn.) Fractions.

Abstract Source:

J Nanosci Nanotechnol. 2019 Apr 1 ;19(4):1996-2007. PMID: 30486940

Abstract Author(s):

Aranya Manosroi, Mathukorn Sainakham, Masahiko Abe, Kenichi Sakai, Nuttanan Sinchaipanid, Worapaka Manosroi, Jiradej Manosroi

Article Affiliation:

Aranya Manosroi

Abstract:

Liposomes, entrapped with Job's Tears fractions, were prepared by the supercritical carbon dioxide fluid (scCO₂) technique with and without sonication. Physical characteristics, which were the particle size, zeta potential, vesicular morphology, microviscosity and bioactivities including anti-proliferative, apoptotic and antioxidative activities of the S1L-S5L liposomal systems, were investigated. The potent anti-proliferative activity with the ICvalue of 4.44±2.31 ug/ml in a colon cancer cell (HT-29) was observed in the S5L. S5L also showed the apoptotic activity of 4.45±0.92% in an HT-29 cell. For antioxidative activities, the S3L showed the highest free radical scavenging activity and lipid peroxidation inhibition, whereas the S4L gave the highest metal chelating activity. This study has demonstrated the potent anti-proliferative activity on an HT-29 cell of the S5L liposomal formulation prepared by the scCO₂ technique which can be further developed towards a novel anticancer drug.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiproliferative : CK(6801) : AC(5032)

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