Abstract Title:

Tanshinone IIA effects on ovarian cancer cell line.

Abstract Source:

J Pharm Pharmacol. 2018 Oct ;70(10):1369-1377. Epub 2018 Jun 25. PMID: 29943422

Abstract Author(s):

Nan Li, Liang Yang, Baolian Zhang, Suqin Chen

Article Affiliation:

Nan Li


OBJECTIVES: To explore the potential therapeutic effect of Tanshinone IIA against ovarian cancer in vitro and elucidate the underlying molecular mechanism.

METHODS: The cell survival upon Tanshinone IIA treatment was determined by the clonogenic assay. Cell apoptosis was analysed by Annexin V/propidium iodide double staining. The cleaved caspase-3/poly ADP-ribose polymerase and apoptosis-related factors were quantified by Western blotting. The relative expression of microRNAs (miRs) was determined by real-time polymerase chain reaction.

KEY FINDINGS: Tanshinone IIA treatment induced significant apoptosis in TOV-21G cells. Tanshinone suppressed survivin expression while not affected Bax, Bcl-2 and Bcl-xL. We further predicted and experimentally confirmed overexpression of miR-205 in TOV-21G, which ectopic significantly inhibited survivin and promoted cell apoptosis. miR-205-specific antagonist completely abrogated the cell suppressive effect of Tanshinone IIA.

CONCLUSIONS: Our data suggested that Tanshinone IIA induced cell apoptosis in ovarian carcinoma TOV-21G cells via direct upregulation of miR-205. Our study highlighted the potential therapeutic application of Tanshinone IIA against ovarian malignancy.

Study Type : In Vitro Study

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Sayer Ji
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