n/a
Article Publish Status: FREE
Abstract Title:

Associations between serum carotenoid levels and the risk of non-Hodgkin lymphoma: a case-control study.

Abstract Source:

Br J Nutr. 2020 Apr 30:1-31. Epub 2020 Apr 30. PMID: 32349798

Abstract Author(s):

Shan Li, Xianglu Zhu, Lin Zhu, Xin Hu, Shujuan Wen

Article Affiliation:

Shan Li

Abstract:

Limited studies have investigated the effects of serum carotenoids on the risk of non-Hodgkin lymphoma (NHL) and the findings have been inconclusive. This study aims to assess the association between serum total or specific carotenoid levels and NHL risk. This 1:1 matched, hospital-based case-control study enrolled 512 newly diagnosed (within 1 month) NHL patients and 512 healthy controls who were matched by age (±5 years) and sex in Urumqi, China. Serum carotenoid levels were measured by high-pressure liquid chromatography. Conditional logistic regression showed that higher serum total carotenoid levels and their subtypes (e.g., α-carotene, β-carotene, β-cryptoxanthin, and lycopene) were dose-dependently associated with decreased NHL risk. The multivariable-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) for NHL risk for quartile 4 (vs. quartile 1) were 0.31 (0.22, 0.48; P for trend:<0.001) for total carotenoids, 0.52 (0.33, 0.79; P for trend: 0.003) forα-carotene, 0.63 (0.42, 0.94; P for trend: 0.031) for β-carotene, 0.73 (0.49, 1.05; P for trend: 0.034) for β-cryptoxanthin, and 0.51 (0.34, 0.75; P for trend: 0.001) for lycopene. A null association was observed between serum lutein+zeaxanthin and NHL risk (OR: 0.89, 95% CI: 0.57, 1.38; P for trend: 0.556). Significant interactions were observed after stratifying according to smoking status, and inverse associations were more evident among current smokers than past or never smokers for total carotenoids, α-carotene, and lycopene (P for heterogeneity: 0.047, 0.042, and 0.046). This study indicates that higher serum carotenoid levels might be inversely associated with NHL risk, especially among current smokers.

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.