Article Publish Status: FREE
Abstract Title:

Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.

Abstract Source:

J Nat Prod. 2013 Jun 28 ;76(6):1064-70. Epub 2013 Jun 19. PMID: 23806111

Abstract Author(s):

Ina L Lauinger, Livia Vivas, Remo Perozzo, Christopher Stairiker, Alice Tarun, Mire Zloh, Xujie Zhang, Hua Xu, Peter J Tonge, Scott G Franzblau, Duc-Hung Pham, Camila V Esguerra, Alexander D Crawford, Louis Maes, Deniz Tasdemir

Article Affiliation:

Ina L Lauinger


Chemicals targeting the liver stage (LS) of the malaria parasite are useful for causal prophylaxis of malaria. In this study, four lichen metabolites, evernic acid (1), vulpic acid (2), psoromic acid (3), and (+)-usnic acid (4), were evaluated against LS parasites of Plasmodium berghei. Inhibition of P. falciparum blood stage (BS) parasites was also assessed to determine stage specificity. Compound 4 displayed the highest LS activity and stage specificity (LS IC50 value 2.3μM, BS IC50 value 47.3 μM). The compounds 1-3 inhibited one or more enzymes (PfFabI, PfFabG, and PfFabZ) from the plasmodial fatty acid biosynthesis (FAS-II) pathway, a potential drug target for LS activity. To determine species specificity and to clarify the mechanism of reported antibacterial effects, 1-4 were also evaluated against FabI homologues and whole cells of various pathogens (S. aureus, E. coli, M. tuberculosis). Molecular modeling studies suggest that lichen acids act indirectly via binding to allosteric sites on the protein surface of the FAS-II enzymes. Potential toxicity of compounds was assessed in human hepatocyte and cancer cells (in vitro) as well as in a zebrafish model (in vivo). This study indicates the therapeutic and prophylactic potential of lichen metabolites as antibacterial and antiplasmodial agents.

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