Article Publish Status: FREE
Abstract Title:

Analysis of adverse events following immunization in Minas Gerais, Brazil, 2011: a cross-sectional study.

Abstract Source:

Epidemiol Serv Saude. 2016 Jan-Mar;25(1):45-54. PMID: 27861677

Abstract Author(s):

Suelem Santos Silva, Valéria Conceição de Oliveira, Helen Cristiny Teodoro Couto Ribeiro, Tamara Gabriela Silva Alves, Ricardo Bezerra Cavalcante, Eliete Albano de Azevedo Guimarães

Article Affiliation:

Suelem Santos Silva


OBJECTIVE: to analyze the main adverse events occurring following immunization in Minas Gerais State, Brazil, in 2011.

METHODS: this is a cross-sectional study using secondary data from the Brazilian Information System on Adverse Events Following Immunization.

RESULTS: 1,449 adverse events were found; more than half occurred in children under one year of age (56.1%; OR=1.39; 95%CI: 1.08;1.78); the highest rates per 100,000 doses administered were found in the Southern Triangle (36.3), Northwest (25.7) and Southern (22.7) areas of the state; tetravalent vaccine had the highest reactogenicity (46.1%) and hypotonic-hyporesponsive episode was the most frequent event (15.9%); events were significantly associated with inactivated vaccines (OR=4.08; 95%CI: 3.51;4.75); most of the reported events were closed as 'undefined' (58.9%).

CONCLUSION: events were found in all regions of Minas Gerais state and were most frequent following administration of inactivated vaccines and among children under one year of age.

Study Type : Human Study
Additional Links
Anti Therapeutic Actions : Vaccination: All : CK(12676) : AC(1344)
Problem Substances : vaccines

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Sayer Ji
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