Article Publish Status: FREE
Abstract Title:

Fucoidan fromInhibits Expression of GLUT9 and URAT1 via PI3K/Akt, JNK and NF-κB Pathways in Uric Acid-Exposed HK-2 Cells.

Abstract Source:

Mar Drugs. 2021 Apr 23 ;19(5). Epub 2021 Apr 23. PMID: 33922488

Abstract Author(s):

Yu Zhang, Xiaohui Tan, Zhen Lin, Fangping Li, Chunyan Yang, Haiying Zheng, Lingyu Li, Huazhong Liu, Jianghua Shang

Article Affiliation:

Yu Zhang


This work aimed to investigate the effect of fucoidan (FPS) on urate transporters induced by uric acid (UA). The results showed that UA stimulated the expression of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) in HK-2 cells, and FPS could reverse the effect. Moreover, UA could activate NF-κB, JNK and PI3K/Akt pathways, but both pathway inhibitors and FPS inhibited the UA-induced activation of these three pathways. These data suggested that FPS effectively inhibited the expression induction of reabsorption transporters URAT1 and GLUT9 by UA, through repressing the activation of NF-κB, JNK and PI3K/Akt signal pathways in HK-2 cells. The in vitro research findings support the in vivo results that FPS reduces serum uric acid content in hyperuricemia mice and rats through inhibiting the expression of URAT1 and GLUT9 in renal tubular epithelial cells. This study provides a theoretical basis for the application of FPS in the treatment of hyperuricemia.

Study Type : Animal Study, In Vitro Study

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