Abstract Title:

Sulforaphane Induces Cell-Cycle Arrest and Apoptosis in Cultured Human Lung Adenocarcinoma LTEP-A2 Cells and Retards Growth of LTEP-A2 Xenografts in Vivo.

Abstract Source:

J Nat Prod. 2008 Oct 15. Epub 2008 Oct 15. PMID: 18855447

Abstract Author(s):

Hao Liang, Baitang Lai, Qipeng Yuan

Article Affiliation:
Abstract:

Sulforaphane ( 1), a glucosinolate-derived isothiocyanate found in the cruciferous vegetable broccoli, is considered an anticarcinogenic component. In the present study, the proliferation and apoptosis induction in human lung adenocarcinoma LTEP-A2 cells by 1 was investigated. Compound 1 caused G 2/M-phase arrest ( p<0.05) and increase of apoptotic cell fraction ( p<0.05) in a time- and dose-dependent manner. Intraperitoneal injection of 1 significantly inhibited growth of LTEP-A2 xenografts in nude mice, and 9 days after tumor cell implantation with 100 mg/kg intraperitoneal injection of 1, the average tumor weights in 1-treated mice was>70% lower than that of the control mice.

Study Type : Transgenic Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.