Abstract Title:

Induction of differentiation in human promyelocytic cells by the isothiocyanate sulforaphane.

Abstract Source:

Platelets. 2004 Aug;15(5):287-92. PMID: 18610742

Abstract Author(s):

Carmela Fimognari, Monia Lenzi, Giorgio Cantelli-Forti, Patrizia Hrelia

Article Affiliation:

Department of Pharmacology, University of Bologna, Italy. [email protected]


BACKGROUND: The consumption of cruciferous vegetables has long been associated with a reduced risk for the occurrence of cancer at various sites. This protective effect is associated with their isothiocyanate content. Sulforaphane (SFN) is by far the isothiocyanate most extensively studied to uncover the mechanisms behind this chemoprotection. In the present study, the ability of SFN to induce cytodifferentiation and apoptosis in a leukemia cell line was investigated. MATERIALS AND METHODS: Cells were treated with different concentrations of SFN (0-100 microM). Analysis of cell differentiation was performed by nonspecific/specific acid esterase activity. Apoptosis induction was performed by flow cytometry. RESULTS: SFN induced cytodifferentiation toward both granulocytic and macrophagic lineage, mediated by the involvement of phosphatidylinositol 3-kinase/protein kinase C. It also caused a significant increase in the apoptotic cell fraction. CONCLUSION: These findings suggest that SFN may be a promising antileukemic agent and should encourage further investigation as regards its chemotherapeutic potential.

Study Type : In Vitro Study

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.