Abstract Title:

A new benzofuranone and anti-HIV constituents from the stems of Rhus chinensis.

Abstract Source:

Planta Med. 2007 Mar;73(3):279-82. Epub 2007 Feb 9. PMID: 17290322

Abstract Author(s):

Qiong Gu, Rui-Rui Wang, Xue-Mei Zhang, Yun-Hua Wang, Yong-Tang Zheng, Jun Zhou, Ji-Jun Chen

Article Affiliation:

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.


A new benzofuran lactone, rhuscholide A (1), was isolated from the stems of RHUS CHINENSIS, together with six known compounds: 5-hydroxy-7-(3,7,11,15-tetramethylhexadeca-2,6,10,11-tetraenyl)-2(3 H)-benzofuranone (2), betulin (3), betulonic acid (4), moronic acid (5), 3-oxo-6 beta-hydroxyolean-12-en-28-oic acid (6) and 3-oxo-6 beta-hydroxyolean-18-en-28-oic acid (7). Based on 1D, 2D NMR (COSY, HMQC, HMBC) and mass (EI-MS, HR-EI-MS) spectral data, the structure of rhuscholide A was deduced to be 5-hydroxy-3-(propan-2-ylidene)-7-(3,7,11,15-tetramethylhexadeca-2,6,10,11-tetraenyl)-2(3 H)-benzofuranone (1). Anti-HIV-1 bioassays IN VITRO revealed that compound 1 possesses significant anti-HIV-1 activity with an EC50 value of 1.62 microM and a therapeutic index (TI) of 42.40. Compounds 2, 4, 5 and 7 showed moderate anti-HIV-1 activities with EC50 values of 3.70, 5.81, 7.49 and 13.11 microM, respectively.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Anti-HIV Agents : CK(133) : AC(84)

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