Abstract Title:

Sunshine-exposure variation of human striatal dopamine D(2)/D(3) receptor availability in healthy volunteers.

Abstract Source:

Prog Neuropsychopharmacol Biol Psychiatry. 2010 Sep 25. Epub 2010 Sep 25. PMID: 20875835

Abstract Author(s):

Hsiang-Yi Tsai, Kao Chin Chen, Yen Kuang Yang, Po See Chen, Tzung Lieh Yeh, Nan Tsing Chiu, I Hui Lee

Article Affiliation:

Department of Psychiatry, St. Martin De Porres Hospital, Chiayi, Taiwan; National Cheng Kung University Hospital, Tainan, Taiwan.


BACKGROUND: In addition to the serotonergic system, the central dopaminergic system has been reported to be correlated with seasonality. The aim of this study was to explore the difference in striatal dopamine D(2)/D(3) receptor availability between healthy volunteers who had a high sunshine exposure and those who had a low exposure. METHODS: Sixty-eight participants were enrolled, and those in the upper and lower quartiles in terms of sunshine exposure were categorized into high- (n=17) and low- sunshine-exposure (n = 18) subgroups. Single photon emission computed tomography with [(123)I] iodo-benzamide was used to measure striatal dopamine D(2)/D(3) receptor availability. RESULTS: Striatal dopamine D(2)/D(3) receptor availability was significantly greater in the subjects with high sunshine exposure than in those with low sunshine exposure (F=7.97, p=0.01) after controlling for age, sex, and smoking status. LIMITATIONS: Different subjects were examined at different time points in our study. In addition, the sex and tobacco use distributions differed between groups. CONCLUSION: The central dopaminergic system may play a role in the neurobiological characteristics of sunshine exposure variation.

Study Type : Human Study
Additional Links

Print Options

Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.