Daily intake ofβ-cryptoxanthin prevents bone loss by preferential disturbance of osteoclastic activation in ovariectomized mice.
J Pharmacol Sci. 2015 Sep ;129(1):72-7. Epub 2015 Aug 22. PMID: 26342276
Althoughβ-cryptoxanthin, a xanthophyll carotenoid, has been shown to exert an anabolic effect on bone calcification, little attention has been paid thus far to the precise mechanism of bone remodeling. Daily oral administration of β-cryptoxanthin significantly inhibited osteoclastic activation as well asreduction of bone volume in ovariectomized mice. In vitro studies revealed that β-cryptoxanthin inhibited differentiation and maturation of osteoclasts by repression of the nuclear factor-κB-dependent transcriptional pathway. Our results suggest that supplementation with β-cryptoxanthin would bebeneficial for prophylaxis and for therapy of metabolic bone diseases associated with abnormal osteoclast activation.