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Abstract Title:

Supplementation of kefir ameliorates azoxymethane/dextran sulfate sodium induced colorectal cancer by modulating the gut microbiota.

Abstract Source:

Food Funct. 2021 Nov 15 ;12(22):11641-11655. Epub 2021 Nov 15. PMID: 34724014

Abstract Author(s):

Xuejun Zeng, Hang Jia, Xiao Zhang, Xin Wang, Zhouli Wang, Zhenpeng Gao, Yahong Yuan, Tianli Yue

Article Affiliation:

Xuejun Zeng

Abstract:

The aim of this study was to investigate the efficacy of kefir on colorectal cancer (CRC)regulating the microbiota structure in the colon using the azoxymethane/dextran sulfate sodium (AOM/DSS) induced CRC mouse model. Mice in the treatment group were orally administered with milk or kefir. The gut microbiota composition was assessed by internally transcribed spacer 2 (ITS2) and 16S rRNA high-throughput sequencing. Furthermore, the biomarkers associated with the gut barrier, inflammation, and cell proliferation regulators were evaluated. The results indicated that the size and the amount of tumor were decreased and the immunity regulators (TNF-α, IL-6, and IL-17a) and oncocyte proliferation indicator (Ki67, NF-κB, and β-catenin) were all decreased. Increased short chain fatty acids (SCFAs) lowered the pH in the colon and helped enhance the intestinal barrier. The/ratio and/ratio were decreased at the phylum level; the relative abundance of probiotics was increased and the pathogenic bacterium (,and) were decreased after supplementation of kefir. Consequently, kefir could regulate the gut microbiota composition and ameliorate AOM/DSS induced colorectal cancer.

Study Type : Animal Study

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