Article Publish Status: FREE
Abstract Title:

Supplementation WithPolysaccharides Reduce Obesity in High-Fat Diet-Fed Mice by Modulation of Gut Microbiota.

Abstract Source:

Front Microbiol. 2021 ;12:719967. Epub 2021 Aug 26. PMID: 34512598

Abstract Author(s):

Mei Yang, Yexin Yin, Fang Wang, Haihan Zhang, Xiaokang Ma, Yulong Yin, Bie Tan, Jiashun Chen

Article Affiliation:

Mei Yang


Lycium barbarum polysaccharides (LBPs) have been proved to prevent obesity and modulate gut microbiota. However, the underlying mechanisms of LBPs' regulating lipid metabolism remain entirely unclear. Therefore, the purpose of this study was to determine whether LBPs are able to modulate the gut microbiota to prevent obesity. The results showed that oral administration of LBPs alleviated dyslipidemia by decreasing the serum levels of total triglycerides, total cholesterol, and low-density lipoprotein-cholesterol and elevating the high-density lipoprotein cholesterol in obese mice. Furthermore, LBP treatment decreased the number and size of adipocytes in epididymal adipose tissues and downregulated the expression of adipogenesis-related genes, including acetyl-CoA carboxylase 1, fatty acid synthase, stearoyl-CoA desaturase 1, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptorγ, and CCAAT/enhancer-binding protein α. 16S rRNA gene sequencing analysis showed that LBPs increased the diversity of bacteria, reduced the/ratio, and improved the gut dysbiosis induced by a high-fat diet; for example, LBPs increased the production of short-chain fatty acid-producing bacteria,, and. LBPs treatment also increased the content of fecal short-chain fatty acids, including butyric acid. These findings illustrate that LBPs might be developed as a potential prebiotic to improve lipid metabolism and intestinal diseases.

Study Type : Animal Study

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