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Abstract Title:

Suppressive effects of aloin on polyphosphate-mediated vascular inflammatory responses.

Abstract Source:

J Asian Nat Prod Res. 2021 Jan ;23(1):89-99. Epub 2020 Feb 20. PMID: 32077313

Abstract Author(s):

In-Chul Lee, Jong-Sup Bae

Article Affiliation:

In-Chul Lee

Abstract:

Human endothelial cells-derived polyphosphate (PolyP) is one of the pro-inflammatory mediators as suggested by the previous reports. Aloin is the major anthraquinone glycoside obtained from thespecies and exhibits anti-inflammatory and anti-oxidative activities. Aloin inhibits PolyP-mediated barrier disruption, the expressions of cell adhesion molecules, and adhesion/migration of leukocyte to HUVEC. PolyP-induced NF-κB activation and the productions of TNF-α and IL-6 were inhibited by aloin in HUVECs. These anti-inflammatory functions of aloin were confirmed in PolyP-injected mice. In conclusion, based on the anti-inflammatory effects of aloin in PolyP-mediated septic response, aloin has therapeutic potentialfor various systemic inflammatory diseases.

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