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Article Publish Status: FREE
Abstract Title:

Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model.

Abstract Source:

PLoS One. 2019 ;14(6):e0216393. Epub 2019 Jun 26. PMID: 31242213

Abstract Author(s):

Yasufumi Saito, Takao Hinoi, Tomohiro Adachi, Masashi Miguchi, Hiroaki Niitsu, Masatoshi Kochi, Haruki Sada, Yusuke Sotomaru, Naoya Sakamoto, Kazuhiro Sentani, Naohide Oue, Wataru Yasui, Hirotaka Tashiro, Hideki Ohdan

Article Affiliation:

Yasufumi Saito

Abstract:

Although synbiotics may be effective in maintaining remission of inflammatory bowel disease, their anticarcinogenic effects are still debated. To address this issue, we evaluated the effects of synbiotics, probiotics, and prebiotics on tumorigenesis using a CDX2P-Cre; Apc+/flox mouse model harboring a colon-specific Apc knock out, which develops adenoma and adenocarcinoma of the colon. Dextran sodium sulfate (DSS)-administration promoted colonic tumor development in CDX2P-Cre; Apc+/flox mice, and these tumors were associated with loss of Apc heterozygosity, as confirmed by observation of well-differentiated adenocarcinomas withβ-catenin accumulation in tumor cell cytoplasm. Synbiotics-treatment suppressed dextran sodium sulfate-induced colitis in CDX2P-Cre; Apc+/flox mice, thereby reducing mortality, and inhibited tumorigenesis accelerated by DSS-administration. Conversely, neither probiotics nor prebiotics had any effect on inflammation and tumorigenesis. Lactobacillus casei and Bifidobacterium breve were detected in the fecal microbiota of probiotics-treated mice. Synbiotics-treatment suppressed DSS-induced expression of IL-6, STAT-3, COX-2, and TNF-α gene transcripts in normal colonic epithelium, indicating thepossibility of suppressing tumor development. Importantly, these genes may be potential therapeutic targets in inflammation-associated colon cancer.

Study Type : Animal Study

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