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Article Publish Status: FREE
Abstract Title:

Activity of Allicin Alone and in Combination With Antifungal Drugs AgainstIsolated From Patients With Tinea Capitis.

Abstract Source:

Front Med (Lausanne). 2021 ;8:783086. Epub 2021 Nov 26. PMID: 34901093

Abstract Author(s):

Ya Bin Zhou, Yuan Yuan Xiao, Jin Jing Chao, Lin Ma

Article Affiliation:

Ya Bin Zhou

Abstract:

The checkerboard broth method based on the Clinical and Laboratory Standards Institute M38-A3 document was used in this study to evaluate theactivity of allicin alone and in combination with the antifungal drugs (griseofulvin, fluconazole, itraconazole and terbinafine) againstisolated from patients with tinea capitis. When allicin was used alone, only weak anti-effects were found. The MIC, MICand geometric mean (GM) of terbinafine were the lowest among the compounds tested. Synergism was observed for the combinations of allicin with itraconazole and terbinafine. Only indifference was observed for the combinations of allicin with griseofulvin and fluconazole. Our study illustrated the synergism of allicin in combination with itraconazole and terbinafine, which could be a reference for the treatment of tinea capitis due to.

Study Type : Human Study

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Sayer Ji
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