Abstract Title:

Synergistic Antioxidant and Antibacterial Activity of Curcumin-C3 Encapsulated Chitosan Nanoparticles.

Abstract Source:

Curr Pharm Des. 2020 Jun 9. Epub 2020 Jun 9. PMID: 32516096

Abstract Author(s):

Desu Naveen Kumar Reddy, Fu-Yung Huang, Shao-Pin Wang, Ramya Kumar

Article Affiliation:

Desu Naveen Kumar Reddy


BACKGROUND: Recent studies have focused on nanoformulations of curcumin to enhance its solubility and bioavailability. The medicinal properties of curcumin-C3 complex which is a combination of three curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) is less explored.

OBJECTIVE: The aim of this study was to prepare curcumin-C3 encapsulated in chitosan nanoparticles, characterize and evaluate their antioxidant and antibacterial potential.

METHODS: Ionic gelation method was used to prepare curcumin-C3 nanoparticles and were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, nanoparticle tracking analysis. In vitro assays were performed to assess drug release, antioxidant and antibacterial activities.

RESULTS: Curumin-C3-chitosan nanoparticle showed an increased entrapment efficiency of>90%, drug release and an improved antioxidant potential. Moreover, curumin-C3-chitosan nanoparticle showed stronger inhibition of Escherichia coli and Staphylococcus aureus.

CONCLUSION: Chitosan is a suitable carrier for curcumin-C3 nanoparticle and can be used as a drug delivery system in the treatment of inflammatory and bacterial diseases.

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Sayer Ji
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