Article Publish Status: FREE
Abstract Title:

Synergistic Effect of Eugenol and ProbioticZs2058 AgainstInfection in C57bl/6 Mice.

Abstract Source:

Nutrients. 2020 May 30 ;12(6). Epub 2020 May 30. PMID: 32486242

Abstract Author(s):

Fanfen Song, Junsheng Liu, Wenyu Zhao, Hongxuan Huang, Diangeng Hu, Haiqin Chen, Hao Zhang, Wei Chen, Zhennan Gu

Article Affiliation:

Fanfen Song


Previously, we showed the preventive effects ofZS2058 (ZS2058) oninfection in murine models. In this work, we found that eugenol has a selective antibacterial effect, which inhibitedmore than probiotics ZS2058 in vitro. It suggested a synergistic effect of them beyond their individual anti-activity. We verified the conjecture in murine models. The results showed that the combination of ZS2058 and eugenol (CLPZE) significantly increased (= 0.026) the survival rate of-infected mice from 60% to 80% and the effect of CLPZE on preventing-infection was 2-fold that of ZS2058 alone and 6-fold that of eugenol alone. CLPZE had a synergistic effect on inhibiting ST growth (the coefficient drug interaction ((CDI) = 0.829), reducing its invasiveness (CDI = 0.373) and downregulating virulence genes' expression in vitro. CLPZE helped the host form a healthier gut ecosystem. CLPZE also elicited a stronger and earlier immune response to systemic infection. In conclusion, these obtained results suggest that ZS2058 and eugenol have a synergistic effect on preventinginfection and open new perspectives in the strategies of controlling the prevalence ofby combination of probiotics and functional food components.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.